These radiopharmaceutical preparations are marked by the isotope 123I (the half-life is 13.27 h, gamma emission quantum is 159 keV).

Jobenguan 123, injection solution (123I-Jobenguan, 123I-MIBG)

  • the active substance is metaiodbenzylguanidine in jobenguan which is an analogue of the adrenergic blocker
  • metaiodbenzylguanidine manifest an affinity to the adrenergic receptor tissue and it is concentrated in the chromaffin cells of the adrenal gland, myocard and other tissues rich in sympathetic part of the vegetative nervous systém
  • the substance is an appliance essential for imaging of the feocytochromes,  neuroblastoma for tumoral detection of the adrenal medulla and their metastases
  • the preparation is also a useful tool for diagnostics in cardiology
  • performing a high specificity to the imaged tissues and very low irradiation exposure of the patient

Hippuran 123, injection solution (123I-Hippuran)

  • the active substance is sodium salt of the orthoiodhippuric acid
  • it is eliminated by renal clearance after intravenous injection (80 % through proximal tubular secretion, the rest through glomerular filtration)
  • the time of the renal throughput is about 4 minutes in healthy patients (the diagnostics of the renal function)
  • the substance has a high sensitivity to the imaging process and very low irradiation exposure of the patient (0.027 mSv/MBq)